Lai H, Li Y, Zhang H, et al, exoRBase 2.0: an atlas of mRNA, lncRNA and circRNA in extracellular vesicles from human biofluids, Nucleic Acids Res, 2022. (IF: 6.75)

Abstract：exoRBase 2.0 is an updated online database dedicated to storing and analyzing long RNAs (exLRs) found in extracellular vesicles (EVs) from various human body fluids. It includes data on over 19,000 mRNAs, 15,000 lncRNAs, and 79,000 circRNAs derived from approximately 1,000 samples of blood, urine, cerebrospinal fluid, and bile. The database not only compares exLR expression but also visualizes functional changes and the heterogeneity of origins of EVs under different physiological and pathological conditions, aiding in the discovery of new biomarkers to improve disease diagnosis and treatment. It can be accessed at http://www.exoRBase.org.

摘要：exoRBase 2.0是一个更新版的在线数据库，专门存储和分析来自多种人体体液的细胞外囊泡（EVs）中的长RNA（exLRs）。它包含了超过19,000个mRNAs、15,000个lncRNAs和79,000个circRNAs的数据，来源于约1000个血液、尿液、脑脊液和胆汁样本。该数据库不仅比较了exLR的表达，还可视化了功能变化和EVs起源的异质性，有助于发现新的生物标志物，以改善疾病诊断和治疗。可通过http://www.exoRBase.org访问。