Ye S, Li Q, Wu Y, et al, Integrative genomic and transcriptomic analysis reveals immune subtypes and prognostic markers in ovarian clear cell carcinoma, Br J Cancer, 2022. ( IF: 6.6)

Abstract: This study is based on comprehensive genomic and transcriptomic analysis aimed at identifying molecular subtypes and prognostic markers of ovarian clear cell carcinoma (OCCC), with a particular focus on immune-related pathways. The study included samples from 50 Chinese patients who underwent targeted next-generation sequencing and transcriptome sequencing. Through hierarchical clustering related to immune pathways, the researchers divided the samples into two subgroups: the immune subgroup (22.0%) and the non-immune subgroup (78.0%). Patients in the immune subgroup had significantly poorer survival rates. The gene expression characteristics of the immune subgroup showed higher expression of pro-inflammatory and immune checkpoint genes, with enrichment of the PD-1 signaling pathway in this subgroup. The study identified an immune subtype of ovarian clear cell carcinoma (OCCC) that is associated with PD-1 signaling and PI3K-AKT-mTOR signaling transduction, and has a poor prognosis.

摘要：本文基于基因组和转录组的综合分析，旨在识别卵巢透明细胞癌的分子亚型和预后标志物，特别关注与免疫相关的途径。研究包括了50名中国患者的样本，这些样本接受了靶向下一代测序和转录组测序。通过免疫途径相关的分层聚类，研究者将样本分为两个亚组：免疫亚组（22.0%）和非免疫亚组（78.0%）。免疫亚组的患者生存率显著较差。免疫亚组的基因表达特征显示促炎和免疫检查点基因表达较高，PD-1信号通路在这一亚组中富集。研究确定了卵巢透明细胞癌（OCCC）的免疫亚型，这一亚型与PD-1信号和PI3K-AKT-mTOR信号转导相关，并且预后较差。