Yu S, Li Y, Liao Z, et al, Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for the detection of pancreatic ductal adenocarcinoma, Gut, 2020. (IF: 23)

Abstract: This study developed a diagnostic based on plasma extracellular vesicle long RNA (exLR) for the detection of pancreatic ductal adenocarcinoma (PDAC). The study involved 501 participants, including patients with PDAC, chronic pancreatitis, and healthy controls. Through exLR sequencing and machine learning algorithms, researchers identified a diagnostic signature comprising eight exLRs that demonstrated high accuracy in training, internal validation, and external validation cohorts. This diagnostic can effectively identify early resectable PDAC and performs better than the traditional carbohydrate antigen 19-9 test in differentiating PDAC from chronic pancreatitis. This finding may contribute to improving early diagnosis and treatment outcomes for patients with PDAC.

摘要：本研究开发了一种基于血浆细胞外囊泡长RNA（exLR）的诊断，用于检测胰腺导管腺癌（PDAC）。研究涉及501名参与者，包括PDAC患者、慢性胰腺炎患者和健康对照组。通过exLR测序和机器学习算法，研究者确定了包含八个exLR的诊断特征，该诊断特征在训练、内部验证和外部验证队列中均显示出高准确性。该诊断能够有效识别早期可切除的PDAC，且在区分PDAC和慢性胰腺炎方面表现优于传统的碳水化合物抗原19-9检测。